Super-enhancers differ from typical enhancers in size, transcription factor density and content, and the ability to activate transcription ( 3). The term ‘super-enhancer’ was used for the first time by Chen et al. Super-enhancers are genome regions that are large clusters of transcriptional enhancers ( 1). Moreover, analytical tools and a genome browser were developed for users to explore super-enhancers and their roles in defining cell identity and disease processes in depth. The response provides detailed (epi)genetic information, incorporating cell type specificity, nearby genes, transcriptional factor binding sites, CRISPR/Cas9 target sites, evolutionary conservation, SNPs, H3K27ac, DNA methylation, gene expression and TF ChIP-seq data. To facilitate data extraction, SEA supports multiple search options, including species, genome location, gene name, cell type/tissue and super-enhancer name. The current release of SEA incorporates 83 996 super-enhancers computationally or experimentally identified in 134 cell types/tissues/diseases, including human (75 439, three of which were experimentally identified), mouse (5879, five of which were experimentally identified), Drosophila melanogaster (1774) and Caenorhabditis elegans (904).
SEA focuses on integrating super-enhancers in multiple species and annotating their potential roles in the regulation of cell identity gene expression.
#Sea archiver archive
Here, we present a specifically designed web-accessible database, Super-Enhancer Archive (SEA, ). The construction of a genome-wide super-enhancer database is urgently needed to better understand super-enhancer-directed gene expression regulation for a given biology process. Super-enhancers are large clusters of transcriptional enhancers regarded as having essential roles in driving the expression of genes that control cell identity during development and tumorigenesis.
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